临床肝胆病杂志2013，Vol.29Issue(2)：146-149,4.
不同年龄组自身免疫性肝炎患者的临床特征分析
Age-related clinical features of autoimmune hepatitis
摘要
Abstract
Objective To analyze and compare the clinical manifestations, biological and chemical indices, immunological indices, and liver biopsy histological features of autoimmune hepatitis ( AIH) according to patient age. Methods Ninety - eight adult Chinese patients diagnosed with AIH were divided into three groups according to age; <45 years old (young) ,45-60 years old (middle -aged) , and >60 years old ( elderly). Significance of inter - group differences in the clinical manifestations, biological and chemical indices, immunological indices, and liver biopsy histology was assessed by ANOVA ( normally distributed data) or Wilcoxon rank test (non - normally distributed data). Results The elderly patients had a significantly higher frequency of hepatopathy than the young patients (50% vs. 20% , P <0. 05) and a higher frequency of cirrhosis than either the young patients (40. 6% vs. 5. 7% , P <0. 05). The elderly patients also had higher levels of total bilirubin (TBil) than the young patients (P < 0. 05 ). The level of serum complement factor 4 ( C4 ) was remarkably lower in the middle - aged patients and elderly patients than in the young patients (P<0.05). The elderly patients had a higher frequency of antinuclear autoantibodies (ANA) positivity but lower frequency of anti - smooth muscle autoantibodies (SMA) positivity than the young patients ( ANA: 100% vs. 77.1% , P < 0.05; SMA: 31.4% vs. 6. 3% , P <0. 05). The middle - aged and elderly patients had higher frequencies of interface hepatitis than the young patients (88.5% and 100% vs. 51.8% , P<0.05). The histology activity index (HAI) was also remarkably higher in the middle -aged and elderly patients than in the young patients (8. 1 ±2.8 and 10.2 ±3.6 vs. 6.6 ±2. 3, P <0. 05). Conclusion Elderly AIH patients have higher frequencies of cirrhosis and complications, as well as stronger inflammatory activities.关键词
肝炎,自身免疫性/年龄组/病理状态/体征和症状Key words
hepatitis, autoimmune/ age groups/ pathological conditions/ signs and symptoms分类
医药卫生引用本文复制引用
李艳丽,赵艳,赵丹彤,张海萍,孙丽梅,马胤雪,胡文静,闫惠平..不同年龄组自身免疫性肝炎患者的临床特征分析[J].临床肝胆病杂志,2013,29(2):146-149,4.基金项目
北京市自然科学基金资助项目(7111004) （7111004）
国家自然基金资助项目(81102265) （81102265）
