临床误诊误治2013，Vol.26Issue(1)：90-93,4.DOI:10.3969/j.issn.1002-3429.2013.01.032
尿道感染大肠埃希菌对喹诺酮耐药性及相关因素分析
Drug Resistance and Risk Factors Analysis of Escherichia Coli Isolated from Urinary Tract Infection to Quinolone
摘要
Abstract
Objective To investigate the drug resistance and risk factors of Escherichia coli isolated from urinary tract infection (UTI) to quinolone. Methods Drug resistance of 705 strains of Escherichia coli isolated from 749 urine specimens of UTI from 2010 to 2011 in our hospital were detected and divided into the resistance group and the sensitive group according to sensitiveness to quinolone, and the risk factors of the quinolone resistance strains were analyzed. Results In 705 strains isolates E. coli, there were 474 strains (67. 2% ) of quinolone resistance in the resistance group, 231 strains (32. 8% ) of quinolone sensitiveness in the sensitive group and there was no carbapenem resistant strain. The differences in resistance rates of amoxicillin/clavulanic acid, cefotaxime, ceftazidime, aztreonam, piperacillin, amikacin, bactrim, gentamicin and cefepime of the two groups were statistically significant (P<0. 05) . Logistic regression analysis showed that the proportion of female patients, drug use of tert-cephalosporins and quinolones, urinary drainage and bacterium producing extended spectrum β lactamases (ESBLS) were independent risk factors of quinolone resistance E. coli. The differences in hospital stay and cost of the two groups were statistically significant (P<0. 05). Conclusion The detection rate of quinolone resistance escherichia coli isolated from UIT is high. The emergence of resistant strains is related to antibiotic application, invasive handling and bacterial variation. To strengthen the independent risk factors regulation can effectively prevent and control spread of infection.
关键词
尿道感染/大肠杆菌/喹诺酮耐药/危险因素Key words
Urinary tract infection/ Escherichia coli/ Quinolone resistance/ Risk factor分类
医药卫生引用本文复制引用
张昭勇,张吉才,杜毅..尿道感染大肠埃希菌对喹诺酮耐药性及相关因素分析[J].临床误诊误治,2013,26(1):90-93,4.
