南京医科大学学报（自然科学版）2013，Vol.33Issue(2)：182-185,4.DOI:10.7655/NYDXBNS20130208
硼替佐米对多发性骨髓瘤干细胞的作用研究
Effects of bortezomib on multiple myeloma stem cells
摘要
Abstract
Objective;To investigate the effect of bortezomib on multiple myeloma stem cells. Methods:In this study,we cultured human multiple myeloma cell lines KMS-11 and the 0CI-MY5 in vitro and set the control group and experimental group of bortezomib treatment. To analyze the proportion of side population cells by using flow cytometry and the mechanism of cancer stem cells efflux Hoechst 33342. Results: After treatment,we found that side population cells were significantly increased. Conclusion:The results indicate that the target of bortezomib is non-side population cells and providing an objective basis for the sequential therapy of bortezomib.关键词
多发性骨髓瘤/肿瘤干细胞/侧群细胞/硼替佐米Key words
multiple myeloma/cancer stem cells/side population cells/bortezomib分类
生物科学引用本文复制引用
朱原辛,李天宇,王婧,周新..硼替佐米对多发性骨髓瘤干细胞的作用研究[J].南京医科大学学报（自然科学版）,2013,33(2):182-185,4.
