南京医科大学学报（自然科学版）2013，Vol.33Issue(2)：191-194,4.DOI:10.7655/NYDXBNS20130210
HIV/AIDS患者KIR3DS1基因与部分环境因素对其疾病进展的影响
Correlation of KIR3DS1 alleles,environmental factors with the progression of HIV-1 infection in HIV/AIDS patients
摘要
Abstract
Objective;To evaluate the correlation of KIR3DS1 alleles,environmental factors with the progression of HIV-1 infection in Chinese population. Methods;In total,86 cases of newly reported HIV/AIDS were recruited from people receiving voluntary counseling and testing(VCT). KIR3DS1 genes was assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Meanwhile,questionnaire survey was conducted to collect the environmental information. Results;Cox regression analysis showde that, compared with non-antivirus treatment group, the risk ratio (RR) of antivirus treatment was 0.217 (95%CI = 0.098-0.480). Conclusion;Antivirus treatment can delay the progression to AIDS,and KIR3DS1 gene may potentially be associated with slower progression to AIDS in Chinese population.关键词
人类免疫缺陷病毒/杀伤细胞免疫球蛋白样受体/环境因素Key words
HIV-1/ killer cell Ig-like receptors/environmental factors分类
生物科学引用本文复制引用
朱一,张学宁,吴建茹,张钰,郭宏雄,傅更锋,徐金水,还锡萍,王蓓..HIV/AIDS患者KIR3DS1基因与部分环境因素对其疾病进展的影响[J].南京医科大学学报（自然科学版）,2013,33(2):191-194,4.基金项目
国家自然科学基金资助(30872156) （30872156）
