青岛大学医学院学报2013，Vol.49Issue(1)：78-80,3.DOI:10.11712/qdyxy201301028
CH-GP凝胶负载富血小板血浆促进牙周再生效果
THE EFFECT OF CHITOSAN/β-GLYCEROL PHOSPHATE GEL LOADING PLATELET-RICH PLASMA ON REPAIRING PERIODONTAL DEFECTS
摘要
Abstract
Objective To observe the effect of injectable chitosan/β-glycerol phosphate (CH-GP) hydrogel loading platelet-rich plasma (PRP) on repairing periodontal defects. Methods This study consisted of 24 class II furcation defect models that were created in the second and third premolars in three healthy male dogs, and divided into groups at random as group A, filled with nothing; group B, filled only with CH-GP hydrogel) group C, filled with PRP; and group D, filled with CH-GP and PRP. The tissue flaps in each group were closely sutured, the gel was injected to the corresponding defected models in groups B, C and D, nothing was done for group A. Eight days postoperatively, the length of newborn alveolar bone (NAB), newborn cementum (NO and newborn periodontal ligaments (NPL) were measured. Results Histologically, the length of NAB, NC and NPL in groups C and D was significantly different as compared with that in group A (F = 6. 54 —11. 37,q = 3. 65 — 9. 84,P<0. 05) and that of the differences between groups C and D were significant as well (q = 3. 12 — 8. 26,P＜0. 05) , but no significant differences were noted between groups A and B in terms of the above items (P>0. 05). Conclusion The CH-GP hydrogel loading with PRP can effectively promote the regeneration of periodontal tissue.关键词
壳聚糖/富血小板血浆/引导组织再生,牙周Key words
chitosan/ platelet-rich plasma/ guided tissue regeneration, periodontal分类
临床医学引用本文复制引用
吴广升,惠光艳,关继东,刘丽霞..CH-GP凝胶负载富血小板血浆促进牙周再生效果[J].青岛大学医学院学报,2013,49(1):78-80,3.基金项目
青岛市科技支撑计划项目(10-3-3-7-1-nsh) （10-3-3-7-1-nsh）
