山东医药2013，Vol.53Issue(9)：4-6,22,4.DOI:10.3969/j.issn.1002-266X.2013.09.002
青藤碱对佐剂性关节炎大鼠行为学特征和滑膜中TNF-α的影响
Influence of adjuvant-induced arthritis rat behavioral characteristics and TNF-α expression in synovium with sinomenine treatment
摘要
Abstract
Objective To investigate the influence of sinnomenine on joint pain and synovium inflammation in adjuvant-induced arthritis rats. Methods 40 rats were randomly divided into control group (n = 10) and adjuvant-induced group ( n = 30). After being modeled, the rats in adjuvant-induced group were randomly divided into model group ( n = 10) , sinnomenine group (n = 10) and methotrexate group (n = 10). From the second day of modeling success, sinomenine group and methotrexate group were given sinomenine and methotrexat intervention for 4 weeks respectively. The behavioral characteristics of rats were observed. HE staining was used to observe synovium pathological changes, ELISA was used to measure the expression of TNF-α in synovium. Results Compared with normal group, pain threshold was significantly lower and TNF-α expressions in synovium were significantly increased in model group (all P ＜ 0.01). Compared with the model group, pain threshold and TNF-α expression were statistically different in methotrexate group and sinomenine group( all P ＜ 0.05). Conclusions SIN could improve the joint pain, decrease TNF-α expression in synovium, and improve the pathological changes; which may be one of its mechanism of action in the treatment of rheumatoid arthritis.关键词
关节炎/疼痛/青藤碱/肿瘤坏死因子α/大鼠Key words
arthritis/ pain/ sinomenine/ tumor necrosis factor-α/ rats分类
医药卫生引用本文复制引用
牟慧,蔡辉,姚茹冰,赵智明..青藤碱对佐剂性关节炎大鼠行为学特征和滑膜中TNF-α的影响[J].山东医药,2013,53(9):4-6,22,4.基金项目
中国博士后科学基金(20090461491). （20090461491）
