山东医药2013，Vol.53Issue(9)：20-22,3.DOI:10.3969/j.issn.1002-266X.2013.09.007
间断性缺氧对小鼠海马tau蛋白异常过度磷酸化的影响
Effects on hyperphosphorylation of tau protein in hippocampus of mouse with intermittent hypoxia
摘要
Abstract
Objective To observe the expression of tau phosphorylation in hippocampus of mouse after intermittent hypoxia ( IH). Methods 30 male Kun Ming mice were divided into the control group (n = 5) and IH group (n = 25). The mice of IH group suffered 8 hours intermittent hypoxia. Morphological changes of nerve cells were observed with HE. The expression of tau phosphorylation (P-tau) and the total of tau protein (T-tau) were examined by immunohistochemistry at 1 h,6h, 12h,24 h,48 h after IH in hippocampus of mouse. Results HE staining results showed that there were dilated intercellular spaces, reduced number of cells and part of hippocampal neurons presented morphological changes after IH. The expressions of P-tau in 6 h, 12 h, 24 h and 48 h in IH group were higher than those in control group( all P ＜0.05) , in 24 h higher than in 6 h, 12 h and 48 h(all P＜0.05) . The lever of P-tau began enhanced at 6 h after IH, up to peak at 24 h. T-tau had no significant differences in all groups (P ＞0.05). Conclusion Intermittent hypoxia could increase hyperphosphorylation of tau protein.关键词
间断性缺氧/tau蛋白/过度磷酸化/阿尔茨海默病Key words
intermittent hypoxia/ tau protein/ hyperphosphorylation/ Alzheimer' s disease分类
医药卫生引用本文复制引用
刘静,杨遥,徐江涛..间断性缺氧对小鼠海马tau蛋白异常过度磷酸化的影响[J].山东医药,2013,53(9):20-22,3.
