实验动物与比较医学2013，Vol.33Issue(1)：52-55,4.DOI:10.3969/j.issn.1674-5817.2013.01.011
基因重组生长激素对慢性阻塞性肺疾病大鼠营养状况及肺功能影响
Effect of Recombinant Growth Hormone on Nutritional Status and Pulmonary Function in COPD Rat
摘要
Abstract
Objective To study the effect of gene recombinant growth hormone (GH) on nutritional status and lung function of chronic obstructive pulmonary disease (COPD) rats. Methods The COPD rats was established through smoking combined with lipopolysaccharide, 16 cases of COPD rats were randomly divided into 2 groups, group GH for growth hormone treatment (8 cases), daily subcutaneous injections of recombinant rat growth hormone 1 mg,7 days of continuous use, group NS (8 cases) with subcutaneous injection of physiological saline. Fifteenth days after treatment, the rat body weight, serum albumin (ALB), transferrin (TRF), prealbumin (PA), creatinine, blood urea nitrogen and glucose of all the rats were detected, and the lung function were evaluated. Results The COPD model conforms to the COPD basic pathological changes. In two groups before treatment weight, albumin, prealbumin, total protein, creatinine, blood urea nitrogen, blood glucose had no significant difference (P>0.05), body weight, albumin, prealbumin, total protein of growth hormone group increase has higher than the control group (P<0.05), creatinine, urea nitrogen were significantly decreased (P<0.05), the glucose increased before and after treatment with growth hormone group, but the difference was not statistically significant (P>0.05). Lung function (FEV0.3, FEV0.3/FVC, PEF) after treatment compared with the saline control group were significantly higher (P<0.05). Conclusions The growth hormone therapy can improve nutritional status and lung function of the stable phase of chronic obstructive pulmonary disease rat.关键词
基因重组生长激素/慢性阻塞性肺疾病(COPD)/营养状况/肺功能Key words
Recombinant growth hormone/ Chronic obstructive pulmonary disease/ Nutritional status/Lung function分类
生物科学引用本文复制引用
文文,柳德灵,官泽金,黄欲海,陈美莲,叶嘉,赖国祥..基因重组生长激素对慢性阻塞性肺疾病大鼠营养状况及肺功能影响[J].实验动物与比较医学,2013,33(1):52-55,4.基金项目
福建省科技计划重点项目(2009Y0038) （2009Y0038）
