陕西医学杂志2013，Vol.42Issue(4)：394-396,3.
盐酸戊乙奎醚对大鼠体外循环转流期间微循环的影响
The effects of penehyclidine hydrochloride on mice microcirculation during extracorporeal circulation
摘要
Abstract
Objective:To observe the effects of penehyclidine hydrochloride(PHC) on mice microcirculation during extracorporeal circulation. Methods: 20 healthy SD rats were selected and randomly divided into two groups: control group and PHC group. PHC 0. 05mg/kg were added to the priming solution of PHC group while C group added same volume of normal saline. Both control group and PHC group were processed extracorporeal circulation for two hours. The observation time was T0 : before extracorporeal circulation; T1 : 1 hour of extracorporeal circulation; T2 :2 hours of extracorporeal circulation. The observation contains blood pressure, heart rate, differential of oxygen pressure between arterial and venous (Pa-vO2) ; Blood lactate; urine volume for two hours of extracorporeal circulation. Results: Blood lactate was lower than that in PHC group in T2 , T3 while Pa-vO2 was higher than than that in C group(P＜0. 05); urine volume for two hours of extracorporeal circulation was higher than that in PHC group(P＜0. 05) Conclusion:PHC can improve the tissue perfusion by ameliorating mice microcirculation during extracorporeal circulation.关键词
微循环/体外循环/盐酸戊乙奎醚/动物,实验/大鼠Key words
Murocivculation /Extracorporeal/ Circulation/ @Penehyclidiue hydrochloride/ Animals, laboratory/ Rats分类
医药卫生引用本文复制引用
龚兴瑞,秦成名,王贤裕,向勇,许先成..盐酸戊乙奎醚对大鼠体外循环转流期间微循环的影响[J].陕西医学杂志,2013,42(4):394-396,3.基金项目
湖北省十堰市科技局指导项目(编号:ZD20111016) （编号:ZD20111016）
