陕西医学杂志2013，Vol.42Issue(4)：412-414,3.
干扰素-α与拉米夫定配伍治疗对慢性乙型肝炎预后的影响
Effects of interferon-α and lamivudine therapy on the prognosis of patients with chronic hepatitis B virus infection
摘要
Abstract
Objective: To investigate the effects of interferon (IFN)- α and lamivudine therapy on the prognosis of patients with chronic hepatitis B virus (HBV) infection. Methods: 456 patients with chronic HBV infection-related liver disease were retrospectively investigated. Results: There were 68, 55 and 365 patients had received IFN- α, lamivudine and without antiviral therapy respectively. Thirty two patients had received IFN- α and lamivudine treatment simultaneously or successively. End stage liver diseases (ESLD) were found in 116 out of 365 patients without antiviral therapy and 10 out of 68 patients received IFN- α treatment, and 13 out of 55 patients received lamivudine(15. 8 months) treatment. Only 2 out of 30 patients who received IFN- α treatment and obtained virological and biochemical response at the end of treatment progressed to ESLD. Conclutions: IFN- α treatment delays clinical progression in patients with chronic hepatitis B by significantly reducing the incidence of end stage liver diseases. Short course of lamivudine treatment failed to significantly improve the prognosis of patients with chronic hepatitis B.关键词
乙型肝炎,慢性/药物疗法/干扰素-α/拉米夫定/治疗应用/终末期肝病Key words
Hepatitis B, Chronic/drug therapy/ @ Interferon- α: Lamivudine/therapeutic use/ @ End stage liver disease分类
医药卫生引用本文复制引用
赵文学,武文华,蔡芝芳,刘拉羊,纪泛扑,邓红..干扰素-α与拉米夫定配伍治疗对慢性乙型肝炎预后的影响[J].陕西医学杂志,2013,42(4):412-414,3.基金项目
陕西省卫生厅科研资金项目(2010H31) （2010H31）
