生殖医学杂志2013，Vol.22Issue(3)：164-166,3.DOI:10.3969/j.issn.1004-3845.2013.03.004
宫颈癌与人端粒酶基因关系的研究
Relationship between cervical cancer and human telomerase gene
摘要
Abstract
Objective: To explore the correlation between cervical cancer and the expression of human telomerase RNA component (TERC) gene and evaluate the significance of detecting TERC gene expression by fluorescence in situ hybridization (FISH) technique for predicting the progress from cervical intraepithelial neoplasia (CIN) to cervical cancer.
Methods; TERC gene expression was detected by the method of FISH in uterine epithelial exfoliated cells from 81 patients including 20 patients in normal group, 28 patients in CIN1 group, 12 patients in CIN2 group, 9 patients in CIN3 group, and 12 patients in cervical cancer group. The correlation between cervical cancer and TERC gene was analyzed.
Results: The positive rate of TERC gene test in normal group was significant lower than CIN1 group, CIN2 group (P<0. 05), CIN3 group and cervical cancer group (P<0. 01) . There was no significant difference between CIN1 group and CIN2 group (P>0. 05) . There was also significant difference between CIN3 group and cervical cancer group (P<0. 05) . The higher malignant degree was, the more significant difference would be (P<0. 01) .
Conclusions: The abnormal expression of TERC gene is closely related with the process of cervical cancer. The FISH technique for detecting TERC gene may be an effective method for helping to diagnose
early cervical cancer.
关键词
宫颈癌/人端粒酶基因/荧光原位杂交/早期筛查Key words
Cervical cancer/Human telomerase gene/Fluorescence in situ hybridization/Early screening引用本文复制引用
李亚波,王卓,杨红英..宫颈癌与人端粒酶基因关系的研究[J].生殖医学杂志,2013,22(3):164-166,3.
