天然产物研究与开发2013，Vol.25Issue(2)：185-189,5.
南海深海链霉菌Streptomyces albiflaviniger SCSIO ZJ28中Elaiophylin的分离鉴定
Elaiophylin from Deep South China Sea-Derived Streptomyces albiflaviniger SCSIO ZJ28
摘要
Abstract
Strain SCSIO ZJ28 was isolated from deep-sea sediment collected in the South China Sea and identified as Streptomyces albiflaviniger SCSIO ZJ28 by analysis of its 16S rRNA gene sequence. The strain was fermented using M-AM2ab medium. Guided by brine shrimp lethality assay and antibacterial activity assay,a macrolide was obtained from the fermentation extract using various chromatography techniques. The compound was identified as elaiophylin (1) on the basis of spectroscopic analyses,including ESI-MS,lH,13C and 2D NMR experiment,and confirmed by single crystal X-ray diffraction.关键词
海洋放线菌/链霉菌属/Elaiophylin/大环内酯/卤虫致死活性/抑菌活性Key words
marine-derived actinomycete/Streptomyces albiflaviniger/elaiophylin/macrolide/brine shrimp lethal activity/ antibacterial activity分类
生物科学引用本文复制引用
张云,周潇,宋永相,陈芸芸,黄洪波,李洁,华燕,鞠建华..南海深海链霉菌Streptomyces albiflaviniger SCSIO ZJ28中Elaiophylin的分离鉴定[J].天然产物研究与开发,2013,25(2):185-189,5.基金项目
中国科学院知识创新工作重要方向项目(KZCX2-YW-JC202,KZCX2-EW-G-12) （KZCX2-YW-JC202,KZCX2-EW-G-12）
国家自然科学基金项目(41106138) （41106138）
广东省科技计划项目(2010B030600010,2011B031200004) （2010B030600010,2011B031200004）
