天然产物研究与开发2013，Vol.25Issue(2)：258-262,5.
迷迭香酸对辐射损伤小鼠造血功能的保护作用
Protective Effect of Rosmarinic Acid on Hematopoietic Function of Radiation-injured Mice
摘要
Abstract
Rosmarinic acid (RA) ,a naturally occurring water-soluble polyphenlic compound,has been reported to protect cells from solar UV and other ionizing radiations recently. Thus, the objective of the present study was to investigate the effect of the p. o. administration of rosmarinic acid (50,100,150,200 mg/kg body weight,b. w. ) on the hematoproi-etic function of 5.5 Gy 137 Cs γ-rays injured mice,through measuring organ indexes,colony-forming units of spleen,bone marrow DNA contents,body weights,number of karyota fermur,white blood cells,red blood cells,blood pelets and concentration of hemoglobin in peripheral blood. The results demonstrated that different doses of RA all showed radioprotec-tive effect to a certain extent,especially the 100 mg/kg group. Furthermore,RA treatments showed an inverse U-shaped dose-response curve,but not the classical dose-dependent relationship.关键词
多酚类化合物/迷迭香酸/辐射损伤/辐射防护剂/造血系统Key words
polyphenlic compound/rosmarinic acid/radiation injuries/radioprotectant/hematopoietic function分类
医药卫生引用本文复制引用
张玉杰,李光强,徐文清,沈秀,施培基..迷迭香酸对辐射损伤小鼠造血功能的保护作用[J].天然产物研究与开发,2013,25(2):258-262,5.基金项目
天津市应用基础及前沿技术研究计划(10JCYBJC14500) （10JCYBJC14500）
中国医学科学院放射医学研究所青年探索基金(ST1219) （ST1219）
