新医学2013，Vol.44Issue(3)：173-175,3.DOI:10.3969/g.issn.0253-9802.2013.03.007
低剂量华法林预防心房颤动患者脑栓塞的临床研究
Clinical study of low-dose warfarin on preventing thromboembolism in preventing patients with atrial fibrillation
摘要
Abstract
Objective: To evaluate the efficacy and safety of low-dose warfarin on preventing cerebral embolism in atrial fibrillation patients. Methods: Eighty-six patients with persistent atrial fibrillation were randomly divided into 2 groups: the observation group of low-dose ( 1. 25 mg/d) warfarin ( n = 43 ) , and the control group of higher dose (2.5 mg/d ) warfarin ( n = 43 ). The dosage of warfarin was adjusted according to the international normalized ratio (INR) when necessary. Events of cerebral embolism and bleeding complications were compared during one year follow-up. Results: There was no sign ificant difference of the cerebral embolism events between the two groups (4. 6% vs 2. 3% ). The bleeding complications in low-dose of warfarin group was significantly lower than that in the higher dose warfarin control group (4. 6% vs 20. 9% , P <0. 05). Conclusion: Low-dose warfarin is safe and effective in preventing cerebral embolism complications in patients with atrial fibrillation.关键词
华法林/心房颤动/脑栓塞Key words
Warfarin/Atrial fibrillation/Cerebral embolism引用本文复制引用
钟耀彬,陈安潮,周佩晓,杨伟民..低剂量华法林预防心房颤动患者脑栓塞的临床研究[J].新医学,2013,44(3):173-175,3.
