摘要
Abstract
Objective To observe the clinical effect of Qiliqiangxin capsule in the treatment of chronic heart failure and assessment of quality of patients' life. Methods Seventy two patients were randomly divided into 2 groups; control group of 34 patients were treated with regular anti failure therapy; therapy group of 38 patients were treated with Qiliqiangxin capsule on the basis of regular therapy. Treatment period were 12 weeks. Hospitalization time, re-hospitalization rate, 6 min walking testing, Minnesota life quality scores, the plasma N terminal pro brain natriuretic peptide( NT-proBNP) , left ventricular ejection fraction (LVEF) and left ventricular end diastolic dimension (LVEDD) were measured by ultrasonic cardiogram. Results After 12 weeks treatment, 6 min walking distance, Minnesota life quality scores, the plasma NT-pro BNP level, LVEF were significantly improved compared with those before treatment in both groups ( P <0.01) , but LVEDD were not promoted significantly ( P >0.05). Besides, the improvement of 6min walking distance, Minnesota life quality scores, LVEF and NT-proBNP in therapy group was superior to the control group ( P <0.05). But there was no difference in LVEDD ( P >0.05). Compared with control group, hospitalization time and re-hospitalization rate were reduced more obviously in therapy group (P <0.05). The total effective rate in treatment group was higher than control group(94.74% vs 79.41 % , P <0.05). Conclusion Qiliqiangxin capsule is effective for the chronic heart failure patients. It has better social and economic benefits.关键词
心力衰竭,慢性/左室射血分数/芪苈强心胶囊/N末端脑钠肽前体Key words
Heart failure, chronic/ Left ventricular ejection fraction / Qiliqiangxin capsule/ N terminal pro brain natriuretic peptide
