医药导报2013，Vol.32Issue(3)：278-281,4.DOI:10.3870/yydb.2013.03.002
参杞强精胶囊对弱精子症模型大鼠精子质量及附睾组织MDA和SOD的影响
Effects of Shenqi Qiangjing Capsule on Sperm Quality, and Epididymic MDA and SOD Levels of the Rat Asthenospermia Model
摘要
Abstract
Objective To investigate the effect of shenqi qiangjing capsule on the sperm quality in ornidazole-induced asthenospermic rats. Methods The rat asthenospermia model was established by intragastric administration of ornidazole at the dose of 400 mg· kg-1 · d-1. Animals were administrated with low, middle and high doses (400,800,1 600 mg · kg · d-1 ) of shenqi qiangjing capsules. The sperm motility, viability, and quantity as well as superoxide dismutase (SOD) and malondialde-hyde ( MDA) levels in epididymis were measured. Results Compared with the normal control, sperm motility was significantly decreased ( P<0.01) , MDA content in epididymis was significantly increased ( P<0.01) , and the SOD activity was significantly reduced (P<0.01) in the model control group. In the mid and high dose group, the sperm motility was increased significantly (P<0.05 and P<0.01, respectively) , and the MDA level was decreased significantly (P<0.01) in comparison with the model control. The SOD activity was enhanced in all three treatment groups ( P<0.05 or P<0. 01) . Conclusion Shenqi qiangjing capsule can improve sperm motility of the male rats with ornidazole-induced asthenospermia, which might be related to modulation of the oxidative stress injury.关键词
参杞强精胶囊/弱精子症/精子活动力/大鼠Key words
Shenqi Qiangjing capsule/Asthenospermia/Sperm motility/Rat分类
医药卫生引用本文复制引用
田元春,张泉,陆海旺,宾彬,梁丽英..参杞强精胶囊对弱精子症模型大鼠精子质量及附睾组织MDA和SOD的影响[J].医药导报,2013,32(3):278-281,4.基金项目
广西壮族自治区卫生厅中医药医院制剂类课题(GZYZ-10-05) （GZYZ-10-05）
广西壮族自治区中医药管理局中医药科技专项课题(GZYZ1101) （GZYZ1101）
