医药导报2013，Vol.32Issue(3)：289-291,3.DOI:10.3870/yydb.2013.03.005
拉莫三嗪对大鼠急性分离海马神经元钠电流的影响
Effect of Lamotrigine on Sodium Current in Acutely Isolated Hippocampal Neurons of Rats
摘要
Abstract
Objective To investigate the effect of lamotrigine (LTG) on sodium channel in acutely isolated hippocampal neurons of rats. Methods The hippocampal neurons of rats at the age of 7-10 d were prepared by chain wire fungus protease E and blowing. The effects of LTG on voltage-dependent sodium channels were determined by using whole-cell patch clamp technique. Results The amplitude of voltage-dependent sodium currents were decreased (15. 35±3.01) % by LTG in a concentration-dependent manner at the dose of 100 μmol · L . Moreover, LTG shifted the activation curve of sodium currents by (3.8±0.9) mV toward depolarization and the steady state inactivation curve of these currents by (1.8±0.9) mV toward hyper-polarization. Conclusion LTG can block voltage-dependent sodium channels.关键词
拉莫三嗪/钠电流/全细胞膜片钳技术Key words
Lamotrigine/Sodium current/Patch-clamp techniques分类
医药卫生引用本文复制引用
笱玉兰,朱遂强,唐明,罗利俊,陈国华..拉莫三嗪对大鼠急性分离海马神经元钠电流的影响[J].医药导报,2013,32(3):289-291,3.基金项目
武汉市卫生局科技项目资助课题(WX09C04) （WX09C04）
