医药导报2013，Vol.32Issue(3)：328-331,4.DOI:10.3870/yydb.2013.03.018
阿司匹林抵抗与血小板膜GPⅡb/Ⅲa受体基因多态性的相关性
Relationship Between Aspirin Resistance and Gene Polymorphism of Platelet Membrane Glycoprotein Ⅱb/Ⅲa Receptor
摘要
Abstract
Objective To explore the correlation between platelet membrane glycoproteina II b/ El a receptor gene polymorphism and aspirin semi-resistance or resistance. Methods A total of 200 elderly patients with coronary heart disease were administrated with aspirin at the dose of 100 mg · d-1 daily for7 days, and platelet aggregation function was measured with aden-osine diphosphate( ADP)and arachidonic acid(AA) as an inducer. PLA2/PLA1 gene polymorphism were detected via polymer-ase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The semi-resistance, resistance as well as sensitivity of aspirin( AR, ASR and AS) were 22. 5% , 16. 5% and 61. 0% , respectively. The frequency of PLA2 allele gene in AR and ASR group was 11.54% , which was higher than the AS group (1.22% ) (P<0.05). Conclusion The PLA2 allele gene of the platelet membrane GP Ⅱ b/ Ⅲ a is associated with aspirin resistance, which may be a marker of genetic susceptibility to aspirin resistance.关键词
阿司匹林抵抗/血小板膜糖蛋白/多态性Key words
Aspirin resistance/ Platelet membrane glycoprotein/ Polymorphism分类
医药卫生引用本文复制引用
刘菊,黄婷,梅群超..阿司匹林抵抗与血小板膜GPⅡb/Ⅲa受体基因多态性的相关性[J].医药导报,2013,32(3):328-331,4.基金项目
武汉市卫生局临床医学科研项目(WX08D05) （WX08D05）
