中国当代儿科杂志2013，Vol.15Issue(3)：216-218,3.DOI:10.7499/j.issn.1008-8830.2013.03.012
小儿脓毒症T细胞亚群变化分析及临床意义
Changes in T cell subsets in children with sepsis, and their clinical significance
摘要
Abstract
Objective To observe changes in T cell subsets in children with sepsis and their prognosis, and to investigate the clinical significance of these changes in the occurrence and development of sepsis. Methods Fifty children with severe sepsis and 150 children with general sepsis were enrolled as subjects, and 50 age-matched healthy children were included as controls. The percentages of CD3 + , CD4 + and CD8 + T cells in peripheral blood and CD4 + /CD8 + ratio were measured by flow cytometry. The pediatric critical illness score (PCIS) was calculated within 24 hours of admission. Results The children with severe sepsis showed significantly lower percentages of CD3 + , CD4+ and CD8+ T cells CD4 + /CD8+ ratio and PCIS than the controls and children with general sepsis (P < 0. 01). Among the 200 cases of sepsis, the percentages of CD3 + , CD4 + and CD8 + T cells, CD4 + /CD8 + ratio and PCIS were significantly lower in the cured group than in the deceased group. Conclusions Children with sepsis have different degrees of cellular immunosuppression, and the degree of cellular immunosuppression is significantly correlated with the severity of the disease. Detection of T cell subsets in peripheral blood is of great significance for evaluating immune function and judging disease severity in children with sepsis.关键词
脓毒症/T淋巴细胞/小儿危重病例评分/儿童Key words
Sepsis/T cell/Pediatric critical illness score/Child引用本文复制引用
袁远宏,肖政辉,张慧,胥志跃,罗海燕,卢秀兰..小儿脓毒症T细胞亚群变化分析及临床意义[J].中国当代儿科杂志,2013,15(3):216-218,3.基金项目
十二五"儿科应急救治相关技术的研究与推广应用"科技支撑项目(2012BAI04B00). （2012BAI04B00）
