中国动脉硬化杂志2013，Vol.21Issue(3)：252-256,5.
替米沙坦与氨氯地平对2型糖尿病合并轻中度高血压患者血管弹性功能改善作用的对比研究
Comparative Study of Telmisartan and Amlodipine Improving Arterial Stiffness in Type 2 Diabetics Mellitus Patients with Hypertension
摘要
Abstract
Aim To investigate the effect of telmisartan and amlodipine on improving the artery stiffness in type 2 diabetics mellitus patients with hypertension.Methods Type 2 diabetics mellitus patients with primary hypertension were randomly assigned to telmisartan (4 mg each day) and amlodipine ( 5 mg each day ) regimen for 6 months ( n = 36 ) . Brachial-ankle pulse wave velocity ( baPWV) was measured by an automatic brachial ankle pulse wave velocity device before the treatment, one-month and six-month after the treatment.Results Systolic blood pressure (SBP) , diastolic blood pressure ( DBP) and pulse pressure ( PP) were significantly decreased in two groups ( P < 0. 01 ). There were no significant changes in heart rate ( HR) , fasting blood glucose ( FBG) , glycosylated hemoglobin Al ( HbAlc) in two groups (P>0. 05). BaPWV was significantly decreased in two groups. In the telmisartan group, amlodipine group, baPWV was respectively 1 763. 48 ±307. 57 cm/s, 1 722. 71 ±274. 67 cm/s before the treatment; was 1 496. 42 ±229. 37 cm/s, 1 550. 12 ±236. 06 cm/s one-month after the treatment; was 1 436. 52±216. 23 cm/s, 1 465. 68 ±237. 79 cm/s six-mo- nth after the treatment. Comparing the baPWV one-month after the treatment to before the treatment (P <0. 001) ; Comparing the baPWV six-month after the treatment to before the treatment, there were significant differences ( P < 0. 001) ; Comparing the baPWV six-month to one-month after the treatment there were significant differences in telmisartan group (P<0.05) ; am-lodipine group (P < 0. 001). The baPWV in one or six months had significantly more changes in the telmisartan group than in the amlodipine group (P<0.05). Conclusions Arterial stiffness of type 2 diabetics mellitus patients with hypertension was improved post telmisartan and amlodipine therapy in proportion to therapy duration. Telmisartan is superior to amlodipine on improving arterial stiffness of type 2 diabetics mellitus patients with hypertension. Continuous anti-hypertensive treatment with telmisartan and amlodipine will have a persistent improvement of the artery flexibility.关键词
高血压/糖尿病/动脉弹性/药物疗法Key words
Hypertension/Diabetes/Artery Elasticity/Drug Therapy分类
医药卫生引用本文复制引用
李岩,马淑梅..替米沙坦与氨氯地平对2型糖尿病合并轻中度高血压患者血管弹性功能改善作用的对比研究[J].中国动脉硬化杂志,2013,21(3):252-256,5.基金项目
辽宁省科学技术计划项目(2011225015) （2011225015）
