局解手术学杂志2013，Vol.22Issue(1)：76-77,79,3.DOI:10.11659/jjssx.1672-5042.2013010033
光动力治疗中重度痤疮的疗效观察
Photodynamic therapy in the treatment of moderate to severe acne
摘要
Abstract
Objective To investigate the safety and compare the efficacy of different concentrations of 5-aminolevulinic acid photodynamic therapy (ALA-PDT)in the treatment of moderate to severe acne. Methods 160 Patients with moderate to severe acne were randomly divided into four groups. One of these groups was directly irradiated with red light (0% ) , and the other three groups were applied with different concentrations (5% ,10% ,20% )of ALA for 3 hours before been irradiated with red light. The treatment were conducted once a week for 4 times in total. The patients were evaluated at the second week, the fourth week, and the sixth week after the last treatment. Adverse effects were recorded at each visit. Results Six weeks after the last treatment, the different effective rates of each group (0% 、5% 、10% , 20% ) were 35.0% 、67.5% 、77.5% 、92.5% respectively. The efficacy of different concentrations (5% ,10% ,20% ) of ALA was superior to that of red light alone. With the elevation of different ALA concentrations, both the effective rate and incidence of adverse reactions increased (all P < 0. 05). Conclusion The clinical effect of ALA-PDT is more effective than that of red light alone in the treatment of moderate to severe acne. The efficacy increases with the increase of ALA concentration, and the incidence of adverse reactions increase as well.关键词
痤疮/氨基酮戊酸/光动力疗法/疗效Key words
acne/aminolevulinic acid/photodynamic therapy/ efficacy分类
医药卫生引用本文复制引用
王莎,刘博强,陈小强..光动力治疗中重度痤疮的疗效观察[J].局解手术学杂志,2013,22(1):76-77,79,3.
