中国临床药理学与治疗学2013，Vol.18Issue(1)：6-10,5.
柚皮苷及柚皮素对高脂模型大鼠单核细胞过氧化物酶体增殖物激活受体-δ水平的影响
Effects of naringin and naringenin on the level of peroxisome proliferator-activated receptors δ in monocyte of diet-induced obese rats
摘要
Abstract
AIM: To study the effects of nar ingin and naringenin on the expression of peroxi some proliferator-activated receptors S(PPAR-S) in peripheral blood monocyte of diet-induced obese rats. METHODS: The experimental ani mals were divided into normal diet control group, high-fat diet control group and high-fat diet groups treated with high or low dose of nar ingin and naringenin, respectively. After treated by high lipid emulsion garage except for normal diet control group, the high-fat diet rat models were established successfully. Then, vehicle (0. 5% CMC) or different dosages of naringin or naringenin had been given to the rats for 8 weeks. The PPAR-S mRNA expression was de tected by reverse transcription polymerase chain reaction ( RT-PCR) , the serum levels of tri glyceride, total cholesterol, high density lipo protein-cholesterol, low density lipoprotein-cholesterol and very low density lipoprotein-choles terol were measured respectively. RESULTS: Compared with the high-fat diet control group, the levels of triglyceride, total cholesterol, low density lipoprotein-cholesterol and very low den sity lipoprotein-cholesterol were decreased in high dose of naringin and naringenin groups (all P<0.01);the level of high density lipoprotein-cholesterol was increased(P<0. 01);the expres sion of PPAR-S mRNA in peripheral blood mon ocyte in high dose of naringin and naringenin groups was increased (P<0. 05). The positive correlation between PPAR-S ( r = 0. 158 , P< 0.05) and triglyceride, total cholestero (r = 0. 147, P<0.05) were observed through corre lation analysis. CONCLUSION: The high dosa ges of naringin and naringenin might reduce the levels of serum lipid and increase the expression of PPAR-S in peripheral blood monocyte.关键词
柚皮苷/柚皮素/高脂/过氧化物酶体增殖物激活受体-δKey words
Naringin/Naringenin/Hyperliidemia/Peroxisome proliferator-activated receptors δ分类
医药卫生引用本文复制引用
杨颖,袁斌,周春阳,程龙献..柚皮苷及柚皮素对高脂模型大鼠单核细胞过氧化物酶体增殖物激活受体-δ水平的影响[J].中国临床药理学与治疗学,2013,18(1):6-10,5.基金项目
四川省教育厅科学研究项目(1026047) （1026047）
