中国临床药理学与治疗学2013，Vol.18Issue(1)：95-99,5.
右美托咪定复合丙泊酚在无痛肠镜检查中的应用
Application of dexmedetomidine combined with propofol used for painless enteroscope
摘要
Abstract
AIM: To investigate the safety and efficacy of dexmedetomidine ( DEX) com bined with propofol for sedation of patients un
dergoing painless enteroscope. METHODS: Six ty six patients with ASA Ⅰ-Ⅱ requiring entero scope were randomized to (Group D, n= 33) and
(Group P, n = 33). After venous passway was conducted, the mean arterial pressure ( MAP ), heart rate(HR), hemoglobin oxygen saturation levels (SpO2) were recorded. Group D received DEX 0. 1 jug/kg and Group P received saline pla cebo 3 mL initial loading dose, followed by propofol 1. 5 mg/kg,according to the body activ ity and operation time, whether to add propofol 30—50 mg or not. And the consumed dose of propofol, the body movement response, respira tory depression were recorded. RESULTS: Com pared with Group D,the total administered dose of propofol, the time of patients awaken, the
body activity in Group P were increased. During the painless anesthesia, propofol could lead to the circulation inhibition and the heartbeat was significantly quickened. Dexmedetomidine has little influence on the circulation, but it induced the decreased of heart rate. CONCLUSION: There were more efficacy and safe for DEX com bined with propofol for sedation of patients un dergoing painless enteroscope.关键词
右美托咪定/丙泊酚/无痛肠镜/副作用Key words
Dexmedetomidine/Propofol/Painless enteroscope/Side effect 分类
医药卫生引用本文复制引用
赵刚,蔡建明,路牧,俞米林..右美托咪定复合丙泊酚在无痛肠镜检查中的应用[J].中国临床药理学与治疗学,2013,18(1):95-99,5.
