中国临床药理学与治疗学2013，Vol.18Issue(1)：103-109,7.
混合促进剂在经皮给药中的应用研究进展
Research progress in application of multi-component mixtures of en-hancers in transdermal drug delivery
摘要
Abstract
Research study showed that multi component mixtures of enhancers had significant permeation enhancing ability than permeation enhancers alone, with low skin irritancy and low systemic toxicity. It can be concluded that multi component mixtures of enhancers, will have a better development, while taking further re search on permeation enhancement mechanism and high-throughput screening method. Accord ing to domestic and foreign literatures, applica tion of multi-component mixtures of enhancers in transdermal drug delivery were presented. The review focused on the following aspects;(1) drug transport across skin;(2) permeation enhancement mechanism;(3) high-throughput screening of transdermal formulations and appli cation practice.关键词
混合促进剂/协同作用/高通量筛选/经皮给药Key words
Multi-component mixtures of enhancers/Synergistic effect/High-throughput screening/Transdermal drug delivery分类
医药卫生引用本文复制引用
俞文英,张亮,陈国神,叶金翠..混合促进剂在经皮给药中的应用研究进展[J].中国临床药理学与治疗学,2013,18(1):103-109,7.基金项目
国家自然科学基金项目(30901871) （30901871）
浙江省医药卫生科技计划(2011KYA002) （2011KYA002）
浙江省科技厅项目(2010F20019) （2010F20019）
