中国临床医学2013，Vol.20Issue(1)：8-9,2.
肝癌肝动脉化疗栓塞治疗对缺氧诱导因子2α表达的影响及其临床意义
Expression of Hypoxia Inducible Factor 2 alpha and Its Clinical Significance in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization
摘要
Abstract
Objective:To investigate the expression of hypoxia inducible factor 2 alpha( HIF-2a) and its clinical significance in patients with hepatocellular carcinoma treated with transarterial chemoembolization(TACE). Methods: HIF-2a mRNA and pro tein levels were detected by quantitative real-time reverse transcription polymerase chain reaction and Western blot in the tissues of hepatocellular carcinoma from patients underwent TACE and operation( study group, n = 30) and patients merely underwent operationCcontrol group, n = 30). Expression of HIF-2a was further studied using immunohistochemistry. Finally,the clinical significance of HIF-2a was analyzed. Results: Expression levels of HIF-2a mRNA and protein were significantly up-regulated in the study group compared with those in the control group(P<0. 05). The level of HIF-2a protein was significantly correlated with overall survival (95 % confidence interval: 0. 442~0. 972,P<0. 05), but not correlated with disease-free survival(P> 0. 05) in patients with hepatocellular carcinoma. Conclusions;TACE treatment significantly increases HIF-2ct expression level, and the level of HIF-2a is correlated with malignant phenotypes of hepatocellular carcinoma.关键词
缺氧诱导因子2α/肝癌/临床意义Key words
Hypoxia inducible factor 2 alpha/Hepatocellular carcinoma/Clinical significance分类
医药卫生引用本文复制引用
孙海香,杨欣荣,徐泱,樊嘉..肝癌肝动脉化疗栓塞治疗对缺氧诱导因子2α表达的影响及其临床意义[J].中国临床医学,2013,20(1):8-9,2.基金项目
国家自然科学基金资助项目(编号:81030038) （编号:81030038）
