中国美容医学2013，Vol.22Issue(3)：349-354,6.
慢性应激抑郁型黄褐斑动物模型建立与现有模型的比较研究
Establishment of Chloasma Guinea pig Model with chronic unpredictable mild stress depression and comparative study of it with existent models
摘要
Abstract
Objective To establish and authenticate the Chloasma Guinea pig Model with chronic unpredictable mild stress depression and comparative study of it with existent models. Methods After the injection of progesterone,chronic unpredictable sequence of mild stressors stimulated them and gave them partially ultraviolet radiation. Results The Guinea pig model of depression had been established successfully at 28th day.Multiple models of progesterone injection and ultraviolet radiation compounding with chronic unpredictable sequence of mild stressors can heighten MDA,depress SOD,and increase melanocytes of skin. Meanwhile,the ethology of this model showed it's syndrome of Depressive position.The guinea pig showed reduced squares crossing and rearing in open-field test, a significantly reduced consumption of preference for sucrose solutions and an increased pure water consumption as compared with control group. Conclusion The multiple factor Chloasma model of chronic unpredictable mild stress depression has been built successfully. Compared with other existing models of MDA,SOD and skin melanocytes objective indicators of change closer to human Chloasma lesions.关键词
黄褐斑/抑郁症/动物模型Key words
chloasma/depression/animal models分类
医药卫生引用本文复制引用
杨鹏,杨慧兰,麦跃,戴勇,孙林潮,鲁东平..慢性应激抑郁型黄褐斑动物模型建立与现有模型的比较研究[J].中国美容医学,2013,22(3):349-354,6.基金项目
2010年广东省深圳市科学技术计划项目基金资助(深圳市科技计划项目编号:201003464) （深圳市科技计划项目编号:201003464）
