中国实用儿科杂志2013，Vol.28Issue(3)：207-209,3.
糖皮质激素受体α亚细胞分布与儿童特发性血小板减少性紫癜激素治疗敏感性研究
A study on the relationship between the subcellular localization of glucocorticoid receptor and treatment sensitivity in child idiopathic thrombocytopenia purpura
摘要
Abstract
Objectives To evaluate the subcellular localization of glucocorticoid receptors α (GRα) in PBMCs and its clinical significance in children with idiopathic thrombocytopenic purpura (ITP). Methods Glucocorticoid receptor α (GRa) subcellular localization was examined by confocal microscopy. Protein phosphorylation was measured by means of Western blot. Results The GRα of sensitive group localized in nucleus, but in the insensitive group the GR localized in cytoplasma after dexamethasone treatment. The expression of GRα showed no significant difference among the groups. Conclusion The abrogation of GRα nuclear translocation may serve as a novel predictor of glucocorticoid resistance in patients with ITP.关键词
特发性/血小板减少性紫癜/糖皮质激素受体/儿童Key words
idiopathic/ thrombocytopenic purpura/ glucocorticoid receptor/ children分类
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张晓岳,王凤玉,薛爱玲..糖皮质激素受体α亚细胞分布与儿童特发性血小板减少性紫癜激素治疗敏感性研究[J].中国实用儿科杂志,2013,28(3):207-209,3.
