中国实用妇科与产科杂志2013，Vol.29Issue(3)：216-218,3.
磷酸酶基因在宫颈癌组织中的表达及其临床意义
The relationship of expression PTEN in cervical carcinoma
摘要
Abstract
Objective We aim to determine the expression of phosphataseand tensin homology deleted on chromosome ten (PTEN) in cervical cancer and to study the relationship of their expression with clinicpathological characteristics and to demonstrate the potential use of them as a prognostic and therapeutic agent. So that to look for the action of the marker in invasion and metastasis especially. Methods Total 59 specimen between Oct., 2009 and Aug., 2011 at our Hospital. Im-munohistochemical streptavidin-biotin-protein-linked peroxidase (SP) method was used to detect the expression of PTEN in 21 cases of CIN tissue, 20 cases of normal cervical tissue, 59 cases of cervical cancer. It was analyzed that the PTEN expression and clinical stage, histological grade and other clinicopathological parameters of relevance. Results PTEN expression in cervical cancer tissues (38. 98%) were significantly lower than those in para-cancerous normal cervical tissue (100. 0%) (P < 0.05). The expression of PTEN was correlated with different stage and lymph node metastasis, and the expression of PTEN was also correlated with histological grade. Conclusions (1) The expression of PTEN in cervical cancer was higher than that in normal cervical tissues and CIN. (2)It suggested that expression of PTEN may play a role in the carcinogenesis of cervical cancer.关键词
宫颈癌/磷酸酶基因/生物学行为/免疫组织化学Key words
cervical carcinoma/ PTEN/ biological behavior/ imunohistochemistry分类
医药卫生引用本文复制引用
刘瑶,车力凡,张玲..磷酸酶基因在宫颈癌组织中的表达及其临床意义[J].中国实用妇科与产科杂志,2013,29(3):216-218,3.
