中国实用内科杂志2013，Vol.33Issue(3)：203-206,4.
前列腺素E1序贯疗法治疗糖尿病肾损伤疗效研究
Sequential treatment of using prostaglandin E1 significantly ameliorates the diabetic kidney injury
摘要
Abstract
Objective To investigate the effect of sequential therapy of using prostaglandin E1 (PGE1) on treatment of Diabetic Kidney Disease (DKD). Methods A prospective and randomized trial was designed for this study. All patients with DKD were randomly divided into two groups. The treatment group were administrated with PGE, through sequential therapy (10 μg bid, 7 -10 days per month, totally 6 months). The control group received single-course PGE, (10 μg bid, 14 days consecutively) All patients were observed between these two groups in respect of 24 h urine protein, 24 h urinary albumin, NAG, β2-MG, RBP, Scr, BUN, ALB etc. Results 1) There was a significant decrease in both sequential therapy group and single-course group on 24 h urine protein, 24 h urinary albumin, NAG, β2-MG, RBP after PGE, treatment(P < 0. 05) accompanied with a large increase on eGFR. 2) In 3 months and 6 months of follow up, the patients receiving sequential therapy exhibited considerably lower measured value in 24 h urine protein, 24 h urinary albumin, NAG, RBP and β2-MG as compared to that of those patients who experienced single-course PGE, treatment, (P < 0. 05) and eGFR was also highly better improved in sequential therapy group than that of single-course group. Conclusion Not only did this study demonstrate that both sequential therapy and single-course treatment of using PGE, would help slow down the progress of diabetic kidney diseases, also it was the first time to show that sequential therapy of PGE, would better protect patients with DKDs from renal injury than single-course treatment using PGE, The safety of administration of PGE, was also guaranteed as well. All these provide promising therapy on long-term efficacy via sequential therapy of PGE, for those patients with DKDs.关键词
糖尿病肾损伤/前列腺素E1/序贯疗法/尿白蛋白肌酐比值Key words
diabetic kidney disease/ prostaglandins E1/ Sequential treatment/ urine albumin-creatinine ratio分类
医药卫生引用本文复制引用
施渝彬,仓艳琴,刘欣颖,宋亚香,彭艾..前列腺素E1序贯疗法治疗糖尿病肾损伤疗效研究[J].中国实用内科杂志,2013,33(3):203-206,4.基金项目
国家自然科学基金资助项目(8117192,81270136) （8117192,81270136）
