中国药房2013，Vol.24Issue(10)：927-929,3.DOI:10.6039/j.issn.1001-0408.2013.10.24
林可霉素联合肝素钠封管在预防ICU中心静脉导管感染中的作用
Effects of Lincomycin Combined with Heparin Sodium against Infection of Central Venous Catheter in ICU
摘要
Abstract
OBJECTIVE: To explore the effect of lincomycin combined with heparin sodium on prevention of infection of central venous catheter in ICU. METHODS: A total of 172 patients underwent central venous catheters were randomized into trial group and control group with 86 cases in each group. Trial group received lincomycin and heparin sodium, and control group received normal saline and heparin sodium to seal up the tube. The rate of catheter infection, results of blood culture for infection cases and adverse drug reaction were compared between 2 groups. RESULTS: The incidences of infection in trial group were 2.33% in 1-2 weeks after cathe-terization and 5.81% in 2-3 weeks after catheterization, and total incidence of infection was 9.30%. They were significantly lower than those of control group (10.47%, 15.12%, 30.23%); there was statistical significance (P<0.05). The positive rate of blood culture in trial group (12.50%) was significantly lower than in control group (53.85%); there was statistical significance (P<0.05). The incidence of adverse drug reaction in 2 groups were 9.30% and 6.98% ; there was no statistical significance (P>0.05). CONCLUSIONS: Lincomycin combined with heparin sodium can prevent the infection of central venous catheter in ICU effectively and safely.关键词
林可霉素/肝素钠/中心静脉导管/感染Key words
Lincomycin/ Heparin sodium/ Central venous catheter/ Infection分类
医药卫生引用本文复制引用
廖益萍,宋于康..林可霉素联合肝素钠封管在预防ICU中心静脉导管感染中的作用[J].中国药房,2013,24(10):927-929,3.
