中国医科大学学报2013，Vol.42Issue(3)：235-239,5.
急性冠脉综合征患者应用负荷剂量的瑞舒伐他汀与阿托伐汀的效果对比
Comparison of Effects of Loading Dose Rosuvastatin versus Atorvastatin Therapy in Non-ST Segment Elevation Acute Coronary Syndrome Patients
高远 1关启刚 1孙宇姣 1李玉泽 1张海山 1田文 1郭亮 1贾大林 1张月兰1
作者信息
摘要
Abstract
Objective To assess the effect of different loading doses of rosuvastatin and atorvastatin treatment in non-ST segment elevation acute coronary syndrome patients during PCI. Methods A total of 188 patients with non-ST segment elevation acute coronary syndrome were randomly assigned to either rosuvastatin group (30 mg before PCI) or atorvastatin group (120 mg before PCI). Periprocedural myocar-dial injury,hs-CRP,IL-l,IL-6,TNF-α,and the incidence of major adverse cardiac events (MACE) were assessed. Results The MACE at 3 and 6 months after operation, the incidence of periprocedural myocardial injury and the inflammation factor levels were lower in rosuvastatin group than the atorvastatin group. Conclusion Compared with atorvastatin group, high loading dose of rosuvastatin therapy showed better effects of anti-inflammation and cardiac protection, and significantly reduced the MACE incidence at both 3 and 6 months after operation.关键词
瑞舒伐他汀/阿托伐他汀/急性冠脉综合征/血管成形术/炎症Key words
rosuvastatin/ atorvastatin/ acute coronary syndrome/ angioplasty/ inflammation分类
医药卫生引用本文复制引用
高远,关启刚,孙宇姣,李玉泽,张海山,田文,郭亮,贾大林,张月兰..急性冠脉综合征患者应用负荷剂量的瑞舒伐他汀与阿托伐汀的效果对比[J].中国医科大学学报,2013,42(3):235-239,5.
