中国药理学通报2013，Vol.29Issue(3)：297-303,7.DOI:10.3969/j.issn.1001-1978.2013.03.001
表观遗传学药物的研究进展
Research progress in the epigenetic drug
摘要
Abstract
During the last decade, expanding studies on the proteins involved in DNA methylation and the post-translational modification of histone made it possible to develop epigenetic drugs. This review summarizes these potential epigenetic drugs which target the key proteins, like DNA methyltransferases, ly-sine demethylases, protein methyltransferases, histone deacety-lases, histone acetyltransferases, bromodomain-containing proteins, and proteins that bind to methylated histones.关键词
表观遗传学/DNA甲基化/DNA甲基转移酶/组蛋白修饰/组蛋白乙酰化/组蛋白去乙酰化酶/组蛋白甲基化Key words
epigenetics/ DNA methylation/ DNA methyltransferases ( DNMTs )/ histone modification/ histone acetylation/ histone deacetylases ( HDACs )/ histone methylation分类
医药卫生引用本文复制引用
张玲,盛树力,秦川..表观遗传学药物的研究进展[J].中国药理学通报,2013,29(3):297-303,7.基金项目
国家科技重大专项(No 2009ZX09501) （No 2009ZX09501）
北京协和医学院博士创新基金(No 2010-1001-001) （No 2010-1001-001）
