中国真菌学杂志2013，Vol.8Issue(1)：26-29,34,5.
伊曲康唑和羟基伊曲康唑体外抗菌活性比较
Comparison of in vitro activities of itraconazole and hydroxyl-itraconazole
郭莉娜 1徐英春 1楮云卓 1吕火祥 1陈冬梅 1佟明庆 1刘勇 1席丽艳 1施毅1
作者信息
摘要
Abstract
Objective The in vitro activities of itraconazole and hydroxyl-itraconazole against clinically important fungi isolates were tested and compared. Methods The yeast isolates were obtained from blood and normal sterile body fluids, and the Aspergillus isolates were from deep respiratory specimens. The yeast isolates were identified by CHROMagar medium , API 20C and microscopy for Aspergillus strains. Broth microdilution testing was carried out according to CLSI document exactly. Results From 10 hospitals, we collected 338 pathgentic fungi, including 281 strains of Candida spp, 37 strains of Aspergillus spp, 18 strains of Cryptococcus neoformans and 2 other yeasts isolates. Itraconazole exhibited good activities to most yeast isolates. The susceptible rate of Candida albicans ,C. tropicallis,C. parapsilosis ,C. krusei were 83. 8% ,70. 8% ,78. 6% ,38. 5% , respectively;more than 50% C. krusei isolates were susceptible dose dependent; respectively. Itraconazole has less susceptibility to C. glabrata . To Cryptococcus neoformans, Aspergillus fumigatus ,A.flavus , the MIC50/MIC90 were 0. 5/0. 5、1/1 、1/1 μg/mL, respectively. The antifungal activity of H-ITZ is similar to ITZ with against isolates tested. Conclusion Itraconazole has good activity against most pathgentic fungi tested, resistant isolates increased among C. glabrata ;the major metabolite of itraconazole has in vitro antifungal activity.关键词
伊曲康唑/羟基伊曲康唑/敏感性/微量肉汤稀释法Key words
itraconazole/ hydroxyl-itraconazole/ antifungal activities/ broth microdilution test分类
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郭莉娜,徐英春,楮云卓,吕火祥,陈冬梅,佟明庆,刘勇,席丽艳,施毅..伊曲康唑和羟基伊曲康唑体外抗菌活性比较[J].中国真菌学杂志,2013,8(1):26-29,34,5.
