摘要
Abstract
Objective To determine the serum Vitamin D (25OHD) and parathyroid hormone (PTH) status in eldery fracture population and estimate its correlation with bone mineral density (BMD). Methods From 2011.8 to 2012.6, totally 146 patients treated in our hospital were involved in this study, including 36 male and 110 female patients. The serum 25OHD and PTH levels of all participants were measured by euzymelinked immunosorbent assay. Sim-ultaneously, BMD at lumbar spine 1-4(L1-4) and hip sites were measured by Dual-energy X-ray energy absorptiometry (DXA). Serum Vitamin D status was classified into 4 groups according to serum 25OHD levels, severe deficiency ( <10 ng/mL) , deficiency (10≤25OHD <20 ng/mL) , insufficiency (20≤25OHD<30 ng/mL) and sufficiency ( ≥ 30 ng/mL) , meanwhile dividing PTH status into 3 groups according to its levels , insufficiency ( <8. 3 pg/mL) , normal (8.3≤ PTH ≤68 pg/mL) , elevated ( > 68 pg/mL ). The participants were divided into 3 groups according to Bone mineral density, T > - 1 was defined as normal group, -1<T<-2.5 was defined as osteopenia group, T ≤- 2. 5 was defined as osteoporosis group. Results Among the 146 patients, including 36 male and 110 female , the level of vitamin D severe deficiency, deficiency, insufficiency and sufficiency were 41 cases (28. 1% ) , 83 cases (56. 8% ) , 18 cases (12. 3% ) and 4 cases (2. 7% ) , respectively. Normol level of PTH was 102 case (69. 9% ) , elevated group was 44 case (30. 1% ) ; Normal bone mineral density group was 16 case (11. 0% ) , bone mass reduced group was 48 case (32. 8% ) , osteoporosis group was 82 case (56. 2% ). The T-scores at femora neck of females between serum 25OHD severe deficiency group and deficiency group are significant difference. There were no significant difference of 25OHD levels between BMD groups (P >0. 05) , but PTH levels between BMD groups were significant difference (P < 0. 05). Association was found between 25OHD level and BMD at lumbar spinel-4 in all patients, and was not found between 25OHD and PTH levesl. Association was found between 25OHD level and BMD at femoral neck and lumbar spine in female. Conclusion Vitamin D deficiency and insufficiency is a quite serious problem in eldery people with fracture. PTH increased in eldery population with fracture. Association was found between 25OHD level and BMD.关键词
25-羟基维生素D/甲状旁腺激素/骨密度/骨质疏松症/骨折Key words
25-hydroxy vitamin D/ parathyroid hormone/ bone mineral density/ osteoporosis/ fracture分类
医药卫生
