中华骨质疏松和骨矿盐疾病杂志2013，Vol.6Issue(1)：74-82,9.DOI:10.3969/j.issn.1674-2591.2013.01.014
间充质干细胞在缺血缺氧环境中的存活情况
Survival of mesenchymal stem cells in ischemia and hypoxia environment
卜建龙 1陶树清 1王宇翔 1张品一 1刘日富1
作者信息
摘要
Abstract
Under physiological conditions, the oxygen pressure in the environment in-vivo of the mesenchymal stem cells ( MSCs) is a state of relatively hypoxia, which is lower than the normal oxygen pressure in the atmosphere outside. While in the environment in-vivo, the oxygen pressure of the lesions where MSCs are transplanted into is much lower due to the injury or ischemia, which greatly affects the survival of MSCs. Studies have found that in ischemia and hypoxia environment, MSCs will start the self anti-apoptotic mechanism, which plays an important role in maintaining cell survival. Besides, by hypoxic preconditioning, drug applying, adequate supply of glucose, adding cytokines and applying techniques of genetic engineering, also the survival of MSCs in ischemic hypoxic environment is also promoted.关键词
间充质干细胞/缺血缺氧/存活率/凋亡/低氧预处理/细胞因子/基因工程Key words
mesenchymal stem cells/ ischemia and hypoxia/ survival/ apoptotic mechanism/ hypoxic precondition/ cytokines/ genetic engineering分类
医药卫生引用本文复制引用
卜建龙,陶树清,王宇翔,张品一,刘日富..间充质干细胞在缺血缺氧环境中的存活情况[J].中华骨质疏松和骨矿盐疾病杂志,2013,6(1):74-82,9.
