中华临床免疫和变态反应杂志2013，Vol.7Issue(1)：36-40,5.
原发性胆汁性肝硬化合并系统性红斑狼疮的临床特点
Clinical Features of Primary Biliary Cirrhosis and Systemic Lupus Erythematosus
摘要
Abstract
Objective To explore the clinical features of the overlap of systemic lupus erythematosus ( SLE) and primary biliary cirrhosis (PBC) , as well as the similarities and differences between overlapped PBC and simple PBC. Methods Medical charts of 12 cases of PBC/SLE inpatients admitted to Peking Union Medical College Hospital from January 2000 to January 2012 were systemically reviewed- 172 cases were compared as controls from the database of PBC patients in PUMCH during the same period- Results 3. 7% PBC patients overlapped with SLE. All the 12 patients with PBC/SLE were female, and their age at the diagnosis were (50. 1 ±9.4) years old; Nince cases were diagnosed as SLE first and PBC later; the other 3 cases ' manifestation were fulfill PBC first and transferred to SLE later. PBC patients co-existed with SLE had lower WBC, Hb, PLT counts and lower serum level of ALP, γ-GT and IgM than simple PBC patients. Conclusions The Coexistence of PBC and SLE is not rare. SLE maybe one of the protective factors of PBC.关键词
肝硬化,胆汁性/红斑狼疮,系统性Key words
liver cinhosis, biliary/ lupus erythematosus, systemic分类
医药卫生引用本文复制引用
王立,杨云娇,张烜,李永哲,张奉春..原发性胆汁性肝硬化合并系统性红斑狼疮的临床特点[J].中华临床免疫和变态反应杂志,2013,7(1):36-40,5.基金项目
卫生公益性行业科研专项(201202004),卫生部临床重点课题"原发性胆汁性肝硬化基础与临床研究" （201202004）
