肿瘤防治研究2013，Vol.40Issue(1)：32-35,4.DOI:10.3971/j.issn.1000-8578.2013.01.009
叶酸纳米偶联紫杉醇在人卵巢癌裸鼠移植瘤中抗肿瘤效应的实验研究
Experimental Research of FR-targeted Liposomal Formulation of Paclitaxel against Human Ovarian Cancer Xenografts in Nude Mice Models
摘要
Abstract
Objective To explore the influence of folic acid receptor (FR)-targeted liposomal formulation of paclitaxel on human ovarian'cancer xenografts in nude mice models. Methods Human ovarian cancer xenografts in nude mice models were established by using of human ovary cancer cell line SKOV3, and randomly divided into 2 groups (n = 8):the FR-targeted liposomal formulation of paclitaxel (the experi ment group) group and the paclitaxel (the control group) group. The volumes and weight of tumor mass were detected, and the tumor inhibitory rates were calculated. The growth curves of xenograft tumors were draw up. Morphological changes and ultramicrostructure of cells were observed with inverted phase contrast microscope and transmission electron microscope,respectively. Meanwhile,cell apoptosis was in vestigated with TUNEL staining. Results The tumor inhibitory rate of the experiment group was 38. 1%,which was significantly lower than that of the control group (P<0. 05). The apoptosis index (AI) of the experiment group was(53. 45 ±6. 82)%. significant difference was found between the two groups(P<0. 01). Conclusions FR-targetcd liposomal formulation of paclitaxel may actively targeting the folic acid receptor,enable to deliver the nanoscale drugs directively into cancer cells, which could increase therapeutic effect of drug largely. Compared to traditional preparations, the novel FR-targeted nanoscale drug may offer a more promising approach for tumor-targeting therapy.关键词
叶酸受体/卵巢癌/紫杉醇/靶向治疗Key words
Folic acid receptor:Ovarian cancer/ Paclitaxel/Tumor-targeting therapy分类
医药卫生引用本文复制引用
陈卫,李红霞..叶酸纳米偶联紫杉醇在人卵巢癌裸鼠移植瘤中抗肿瘤效应的实验研究[J].肿瘤防治研究,2013,40(1):32-35,4.基金项目
北京市科委资助项目(Z080507030808028) （Z080507030808028）
