摘要
Abstract
Objective To explore the effect of late gastric cancer chemotherapy on expression of TAM CEA,CA72-4 and clinical significance. Methods Application of the method of electrochemical immune shine gastric cancer patients in 49 cases before and after chemotherapy was used to detect plasma CEA and CA72-4;The biochemical method was used to test plasma TAM in patients compared with controls. Results In patients with advanced stomach cancer after chemotherapy,the plasma levels of TAM,CEA. CA72-4 were (99.00+17.00) u/ml,(24. 17 + 7.54) ng/ml, (48. 44 ± 17. 36) u/ml, respectively. And in control group,they were(70. 00 ± 12. 00 )u/ml,(4.24 ±1.28) ng/ml, (5. 49 ± 1. 89 ) u/ml respectively. There was significant difference ( P<0. 01 ). Sub group analysis showed that chemotherapy effective cases (PR+ SD),the TAM level before chemotherapy or after chemotherapy was(123. 00 ± 21. 00) u/ml or (97. 00 ± 16. 00)u/ml,respectively;CEA and CA72-4 were (25. 80 ± 2. 57) ng/ml, (47. 69 ± 13. 19) u/ml or (21. 56 ± 7. 87) ng / ml, (38. 47 ± 14. 23)u/ml. respectively. The difference was statistically significant (P<0. 01 . P<0. 05). In clinical progress of cases (PD) .the levels of TAM and CEA before chemotherapy or after chemotherapy were(117. 00 ± 18. 00)u/ml and(21. 34 ± 5. 68) ng/ml or were (140. 00+ 17. 00 )u/ml and (30. 94 ± 8. 79) ng ml, respectively. The difference had statistical significance (P< 0. 01); CA72-4 before or after chemotherapy was (41. 78 ± 11. 99 )u/ml or(50. 34 ± 17. 06 ) u/ml. respectively. The difference was also statistically significant(P<0. 05). Conclusion TAM,CEA,CA72-4 united detection can be used as evaluation index of chemotherapy curative effect for earlier forecast. 关键词
TAM/CEA/CA72-4/晚期胃癌Key words
TAM/CEA/CA72-4/Late-stage gastric cancer分类
医药卫生
