肿瘤防治研究2013，Vol.40Issue(1)：83-86,4.DOI:10.3971/j.issn.1000-8578.2013.01.021
骨桥蛋白、survivin及bcl-2在宫颈病变中的表达及临床意义
Expression and Significance of Osteopontin,survivin and bcl-2 in Cervical Neoplasms
朱燕 1杨其昌 1刘宏斌 1张晓娟 1沈屹 1刘曼华1
作者信息
摘要
Abstract
Objective To study the expressions and clinical significance of osteopontin(OPN), survivin, bcl 2 in cervical intraepithelial neoplasia(CIN) and cervical carcinoma. Methods By immunohistochemystry method(S-P), the expressions of OPN, survivin and bcl-2 in 74 cases of cervical carcinoma, 20 cases of high grade CIN (H-CIN) ,20 cases of low grade CIN(L-CIN) and 24 cases of chronic cervicitis were ex amined. Results The expressions of OPN,survivin and bcl-2 were obvious difference among four groups (P<0.01). And there was obvious difference between cervical carcinoma, H-CIN,L-CIN and chronic cervicitis (P<0. 05). There was statistically significant correlation between L-CIN and cervical carcinoma (P<0. 05) ,but not H-CIN and cervical carcinoma (P>0. 05). The expression of OPN was positively associated with survivin,bcl-2(P<0. 01) ,and it was also positively associated with differentiated grade,FI-GO staging and lymph nodal involvement (P<0. 05). Conclusion OPN was more highly expressed in cervical carcinomas,which suggested that OPN was intimately correlated with growth and development of cervical carcinoma. And there was intimate correlation between the expression of OPN and survivin,bcl-2 in cervical intraepithelial neoplasia and cervical carcinoma. 关键词
骨桥蛋白/生存素/bcl-2/宫颈癌/宫颈上皮内瘤变Key words
Osteopontin/ survivin/ bcl-2 / Cervical carcinoma/Cervical intraepithelial neoplasia分类
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朱燕,杨其昌,刘宏斌,张晓娟,沈屹,刘曼华..骨桥蛋白、survivin及bcl-2在宫颈病变中的表达及临床意义[J].肿瘤防治研究,2013,40(1):83-86,4.
