肿瘤防治研究2013，Vol.40Issue(2)：180-184,5.DOI:10.3971/j.issn.1000-8578.2013.02.014
Notch2在喉鳞状细胞癌中的表达及意义
Expressions and Significance of Notch2 Protein in Laryngeal Squamous Cell Carcinoma
摘要
Abstract
Objective To investigate the expressions of Notch2 protein in laryngeal carcinoma cells (Hep-2) and the relationship between the expression and the clinical and pathological data in laryngeal carcinoma. Methods The expressions of Notch2 in 95 cases of laryngeal carcinoma tissue and 31 cases of vocal cord polyps,as well as laryngeal carcinoma cells (Hep-2),were detected by QDs-IgG conjugate immuno-fluorescence staining,and the relationship of the expressions of Notch2 to clinical and pathological features of laryngeal carcinoma was analyzed. Results The expression positive rate of Notch2-positive in laryngeal carcinoma was 92. 6% (88/95), and higher than that in vocal cord polyp (32. 3%) (P<0. 01). Notch2 expression was mainly localized in the nucleus. Notch2 expression in laryngeal carcinoma was significantly associated with clinical stage (P<0. 05). The higher clinical stage had higher expression rate. Notch2 expression in laryngeal carcinoma was significantly related to T classification,clinical stage, histo-logical grade and lymph node metastasis (P<0. 05). Laryngeal carcinoma cells Hep-2 had the Notch2 expression and mainly was localized in the cytoplasm and enveloped membrane. Conclusion Notch2 played an important role in development of laryngeal carcinoma,and might be a new molecular target for laryngeal carcinoma.关键词
喉鳞状细胞癌/Notch2蛋白/量子点/免疫荧光Key words
Laryngeal squamous cell carcinoma/Notch2 protein/Quantum Dots/Immunofluorescence分类
医药卫生引用本文复制引用
丁永军,张建斌,李曼,陈晨,韩继波,陶泽璋,陈始明..Notch2在喉鳞状细胞癌中的表达及意义[J].肿瘤防治研究,2013,40(2):180-184,5.基金项目
国家自然科学基金资助项目(81172569) （81172569）
