中医药学报2013，Vol.41Issue(1)：24-26,3.
补肾健脾益气法对酒精性骨质疏松大鼠骨密度(BMD)、骨矿含量(BMC)影响的研究
Influence of the Method of Tonifying Kidney, Strengthening Spleen and Supporting Qi on Bone Mineral Density(BMD) and Bone Mineral Content(BMC)with Alcoholic Osteoporosis(AOP) in Rats
摘要
Abstract
Objective: To observe the influence of the method of tonifying kidney, strengthening spleen and supporting Qi on bone mineral density (BMD) and bone mineral content (BMD) with Alcoholic osteoporosis (AOP) in rats, and to investigate the mechanism of herbs for strengthening kidney and spleen on AOP. Method: 40 adult male SD rats of pathogen - free were randomly divided into four groups on average: model group, western medicine control group, Chinese medicine intervention group and normal control group. The animal model of AOP was induced by irrigation stomach with the Red Start ( Hongxing) Erguotou ( rats in normal control group received saline) , simultaneously, saline, Calcium Carbonate alpha D3, JianGuLing capsule and saline were given to four groups, respectively. Sixteen weeks later, BMD and BMC of thighbone were measured by dual energy X - ray absorptiometry. Results: BMD and BMC in model group were remarkablely decreased compared with normal control group, the difference was significant(P ＜0. 01) , which suggested that rats receiving high concentrations of liguor for 16 weeks really resulted in decrease of BMD and BMC. Furthermore, BMD and BMC in Chinese medicine intervention group(P ＜ 0.01) and western medicine control group (P ＜ 0.05) were remarkablely increased compared with model group. In addition, BMD and BMC in Chinese medicine intervention group were higher than those in Western medicine control group(P ＜ 0.05) , suggesting that Chinese medicine intervention group was superior to western medicine control group. Conclusion: Rats with AOP possess bone metabolism disorder, bone formation decreasing, bone loss reducing and finally induced osteoporosis. The method of tonifying kidney, strengthening spleen and supporting Qi can enhance BMD and BMC, and inhibit loss of bone mineral in rats with AOP, thereby it can effectively improve bone metabolism of rats with AOP.关键词
补肾健脾益气法/酒精性骨质疏松/骨密度/骨矿含量Key words
Method of tonifying kidney, strengthening spleen and supporting Qi/ Alcohol - induced Osteoporosis/ Bone mineral density/ Bone remodeling contents分类
医药卫生引用本文复制引用
任树军,邢国利,姜益常,葛明富,毕旭伟..补肾健脾益气法对酒精性骨质疏松大鼠骨密度(BMD)、骨矿含量(BMC)影响的研究[J].中医药学报,2013,41(1):24-26,3.基金项目
黑龙江省中医药管理局科研基金资助项目(NO.ZHY10-W22) （NO.ZHY10-W22）
