南方医科大学学报2013，Vol.33Issue(4)：474-478,5.DOI:10.3969/j.issn.1673-4254.2013.04.03
ROS融合基因不是中国胆管癌病人的常见表达基因
ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma
摘要
Abstract
Objective To investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).Methods RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-W patients for detection of ROS fusions involving Fused in Glioblastoma (FIG),solute carrier protein (SLC34A2)and major histocompatibility complex class II invariant chain (CD74).Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.Results In all the 56 CCA samples,80.4％ (45/56) were positive for SERPINA1 expression as evaluable samples.Of these evaluable samples,none expressed the ROS fusions.Conclusion ROS fusions are not common in Chinese CCA patients.关键词
ROS融合基因/胆管癌/RT-PCRKey words
ROS fusions/ cholangiocarcinoma/ reverse transcriptional polymerase chain reaction引用本文复制引用
刘鹏敏,武雅君,孙丽,左强,石敏..ROS融合基因不是中国胆管癌病人的常见表达基因[J].南方医科大学学报,2013,33(4):474-478,5.基金项目
吴阶平医学基金(3206740.10017) （3206740.10017）
Supported by Wu Jieping Medical Foundation (Grant number 3206740.10017) （Grant number 3206740.10017）
