南方医科大学学报2013，Vol.33Issue(4)：502-506,5.DOI:10.3969/j.issn.1673-4254.2013.04.08
中医辨证治疗慢性肾脏病蛋白尿的多中心前瞻性临床研究
Syndrome differentiation-based treatment with traditional Chinese medicine for proteinuria in patients with chronic kidney disease: a randomized multicenter trial
摘要
Abstract
Objective To evaluate the clinical efficacy of syndrome differentiation-based treatment with traditional Chinese medicine (TCM) versus losartan therapy in addition to basic treatment for management of proteinuria in patients with chronic kidney disease. Methods This multicenter, randomized, and case-controlled clinical trial was conducted among 81 consecutive patients meeting the inclusion criteria. The patients were randomized consecutively to receive TCM treatments according to the syndrome patterns in TCM (spleen and kidney Qi and Yin deficiency, and spleen and kidney Qi and Yang deficiency, n=60) or oral losartan therapy (50 mg/day, n=21) in addition to the basic treatments. All the patients were followed up for 24 weeks to observe the clinical effects. Results The patients in TCM group showed a significantly higher overall response rate (93.33%) than those in losartan group (76.20%, P0.05). The TCM score in the two groups were all decreased at week 24 as compared with baseline (P0.01 or P0.05). The TCM scores in both groups decreased significantly after the treatments as compared with the baseline scores (P0.05). After a 8-week-long treatment, Scr, eGFR and Cys-C, U-Pro/24 h, and MA/Cr all decreased significantly in TCM group (P0.05) but showed no significant changes in losartan group (P>0.05). Conclusion Syndrome differentiation-based TCM treatment in addition to basic treatments can produce satisfactory therapeutic effects on proteinuria in patients with chronic kidney disease by improving the clinical symptoms, reducing TCM symptom scores and proteinuria, and protecting the renal functions.关键词
慢性肾脏病/蛋白尿/中医辨证组方/氯沙坦Key words
chronic kidney disease/ syndrome differentiation-based treatment/ proteinuria/ traditional Chinese medicine/ losartan引用本文复制引用
王东,吴同茹,谢婷婷,彭文,王怡,袁敏,米秀华,毕月萍,何立群..中医辨证治疗慢性肾脏病蛋白尿的多中心前瞻性临床研究[J].南方医科大学学报,2013,33(4):502-506,5.基金项目
国家自然科学基金(81173219) （81173219）
科技部中医药行业科研专项(201007005) （201007005）
教育部高等学校博士点专项科研基金(20093107110006) （20093107110006）
上海市科委创新行动计划项目(11DZ1973100) （11DZ1973100）
上海高校创新团队建设项目(第二期) （第二期）
