南方医科大学学报2013，Vol.33Issue(4)：546-549,4.DOI:10.3969/j.issn.1673-4254.2013.04.18
血清与卵泡液抗苗勒氏管激素对多囊卵巢综合症患者体外受精-胚胎移植临床结果的预测价值
Predictive value of anti-Müllerian hormone levels in serum and follicle fluid for IVF-ET outcomes in patients with polycystic ovarian syndrome
摘要
Abstract
Objective To investigate the association of anti-Müllerian hormone (AMH) levels in the follicular fluid and serum with the outcomes of in vitro fertilization-embryo transfer (IVF-ET) cycles in patients with polycystic ovarian syndrome (PCOS). Methods Serum and follicular fluid samples were obtained from 30 patients with PCOS and 34 healthy women (control) undergoing IVF/ICSI-ET in our center between October, 2007 and January, 2008. All the subjects received treatment with long luteal-phase down-regulation and controlled ovarian hyperstimulation protocol in IVF cycles, and their clinical characteristics were analyzed. The AMH levels in the serum and follicles fluid samples collected on the day of oocyte retrieval were assayed using an enzyme-linked immunosorbent assay (ELISA) kit. Results The two groups showed no significant differences in the mean age, baseline levels of sex hormones, rate of high-quality embryos, implantation rate, pregnancy rate, abortion rate or ongoing pregnancy rate (PXD.05). Despite a significantly lower total gonadotropin dose, PCOS group had a significantly greater number of antral follicles than the control group (P0.05). The recovery rates of oocytes in PCOS group were significantly lower than that in the control group (P0.05). AMH levels in the serum and follicle fluid was significantly higher in PCOS group than in the control group (P0.05), and in both groups, AMH levels in the follicular fluid were significantly higher in pregnant women than in non-pregnant women (P0.05). AMH level in the follicular fluid was significantly correlated with the implantation rate in both PCOS and control groups (P0.05). Conclusion AMH level in the serum and follicle fluid on the day of oocyte retrieval is predictive of the treatment outcome of controlled ovarian hyperstimulation in POCS patients but not of pregnancy outcomes after IVF-ET.关键词
抗苗勒氏管激素/多囊卵巢综合症/体外受精-胚胎移植Key words
anti-Muüerian hormone/ polycystic ovarian syndrome/ in vitro fertilization-embryo transfer引用本文复制引用
陈薪,尹敏娜,叶德盛,何于夏,陈士岭..血清与卵泡液抗苗勒氏管激素对多囊卵巢综合症患者体外受精-胚胎移植临床结果的预测价值[J].南方医科大学学报,2013,33(4):546-549,4.基金项目
国家自然科学基金(81170574) （81170574）
广东省中国科学院全面战略合作项目(20100908) （20100908）
广州市科技计划项目重点项目(11C22120737) （11C22120737）
