摘要
Abstract
Objective: To investigate the clinical efficacy and safety of flunarizine hydrochloride as ad-junctive therapy in patients with refractory epilepsy. Method: Based on a randomized double-blind, 90 patients with refractory epilepsy patients were randomly divided into observation group and the control group, 45 cases in each group. The control group was given traditional antiepileptic drug treatment, the observation group, the addition of hydrochloric acid in the treatment of the control group on the basis of flunarizine ( FNZ ). Compared treatment efficacy of two groups after 3 months. Result: In the observation group, the total effective rate was 85. 3% ,which was higher than that of control group ( 66. 7% ), the difference was statistically significant ( P < 0. 05 ). The seizure frequency and baseline seizure frequency significantly decreased after one month and 3 months treatment in two groups, the difference was statistically significant ( P < 0. 01 ). 3 months after treatment, seizure frequency in observation group was decreased significantly, the difference was statistically significant ( P < 0. 01 ). After treatment, EEG also improved in two groups, but compared before and after treatment, there was no statistically significant difference ( P > 0. 05 ). There was no obvious adverse reaction in the observation group . Conclusion: Flunarizine hydrochloride as refractory epilepsy add-on therapy is effective and safe.关键词
难治性癫痫/盐酸氟桂利嗪/辅助治疗Key words
Refractory epilepsy/Flunarizine hydrochloride/Adjuvant treatment
