郑州大学学报（医学版）2013，Vol.48Issue(2)：204-207,4.DOI:10.3969/j.issn.1671-6825.2013.02.016
脊索瘤组织中Brachyury 表达与预后的关系
Relationship between expression of Brachyury in chordoma tissue and prognosis
摘要
Abstract
Aim:To research the association of expression of Brachyury with the prognosis of chordoma. Methods:A total of 78 cases of chordoma tissues, 7 cases of notochord controls near chordoma tissue and 6 cases of embryonic noto-chord tissue were collected to construct tissue microarray, and immunohistochemistry was used to detect the expression of Brachyury. A total of 57 chordoma patients were followed up, 27 patients were alive without evidence of disease, 7 patients were alive with disease, and 23 patients died of chordoma. Results:Brachyury expression were positive in 75. 64% ( 59/ 78 ) chordoma tissue, 4/7 notochord normal controls and 6/6 embryonic notochord tissue. Brachyury positive expression level in chordoma tissue did not differ from that of notochord normal tissue( H = 22. 669 ,P =0. 263 ). Brachyury positive expression rate in mobile spine was lower than that in sacrum group( H = 2. 292 ,P = 0.022 ). There were no significant differences among patients with different disease status in Brachyury expression( H = 2. 605 ,P = 0. 272 ), and the survival curves of patients with different Brachyury expression level had no difference(X2= 0. 432, P =0. 933 ). Conclusion:Brachyury can not be used as specific biomarker to predict the prognosis of chordoma.关键词
脊索瘤/Brachyury/预后Key words
chordoma/Brachyury/prognosis分类
医药卫生引用本文复制引用
张琳琳,张展,段震峰..脊索瘤组织中Brachyury 表达与预后的关系[J].郑州大学学报（医学版）,2013,48(2):204-207,4.
