郑州大学学报（医学版）2013，Vol.48Issue(2)：225-228,4.DOI:10.3969/j.issn.1671-6825.2013.02.022
高效液相色谱法测定枸橼酸他莫昔芬凝胶剂在大鼠组织内的分布
Tissue distribution of transdermal administration of tamoxifen citrate gel in female adult rats by HPLC
朱玲 1邵彦江 1李敏 1崔文琪 1阿有梅 1高珊珊 1张振中1
作者信息
摘要
Abstract
Aim:To study the tissue distribution of tamoxifen after transdermal administration of tamoxifen citrate gel on the breast skin of rats. Methods:Fifty female rats were randomly allocated into 2 groups( 25 in each group ). Experiment group received transdermal tamoxifen citrate gel once per day at 50 mg/kg for 3 days, and control group received tamoxifen citrate solution at 10 mg/kg for 3 days. The rats were sacrificed at 0, 4, 8, 12, 24 h after the last administration. The concentrations of tamoxifen in breast, womb, ovary and liver were determined by HPLC. Results:Peak concentration ( Cmax ) of tamoxifen in breast of the two groups both occurred at 4 h following last administration. The Cmax of tamoxifen in breast of the experiment group was significantly higher than that in the control group at different time points( t = 7.183.7.788.8.078.5.804 and 5. 442,P <0.001 ). There was no significant difference in the concentration of tamoxifen from other tissue of the 2 groups at different time points( P > 0.05 ). Conclusion:Tamoxifen has more satiafactory distribut ion the breast tissue after transdermal administration of tamoxifen citrate gel compared with oral administration.关键词
他莫昔芬/凝胶剂/大鼠Key words
tamoxifen/gel/rat分类
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朱玲,邵彦江,李敏,崔文琪,阿有梅,高珊珊,张振中..高效液相色谱法测定枸橼酸他莫昔芬凝胶剂在大鼠组织内的分布[J].郑州大学学报（医学版）,2013,48(2):225-228,4.
