临床小儿外科杂志2013，Vol.12Issue(2)：100-102,3.DOI:10.3969/j.issn.1671-6353.2013.02.007
Kai1/CD82表达水平与神经母细胞瘤转移的关系探讨
The relationship between Kai1/CD82 expression and metastasis of neuroblastoma
摘要
Abstract
Objetive To investigate the relationship between Kail / CD82 expression and metastasis of neuroblastoma. Methods RT-PCR shall be applied to test the expression of KailmRNA in 40 neuroblastoma paraffin specimens of each period. Kail/CD82 level was measured by immunohistochemistry method in 40 neuroblastoma paraffin specimens of each period. Results RT-PCR shows that the relative content of KailmRNA in in the neuroblastoma group with lymph node or distant metastasis is 0. 0748 ±0. 0063 ,the relative content of KailmRNA in the neuroblastoma group without metastasis is 0. 75 ± 0. 03 , there is statistical significance in the two group difference. The positive rate of Kail/CD82 expression was 71.43% in the neuroblastoma group without metastasis and 31. 58% in the neuroblastoma group with lymph node or distant metastasis. There was a significant difference in the Kail/CD82 expression between neuroblastoma groups with and without metastasis. There was no significant differences in the Kail/CD82 expression between metastasis neuroblastoma groups with and without bone marrow infiltration. Conclusions The expression level of Kail/CD82 can be used as a potential predictor of metastasis of neuroblastoma.关键词
神经母细胞瘤/肿瘤抑制基因/Kai1/CD82Key words
Neuroblastoma/ Tumor Suppressor Genes/ Kail/CD82引用本文复制引用
顾涛,鹿洪亭,董蒨
..Kai1/CD82表达水平与神经母细胞瘤转移的关系探讨[J].临床小儿外科杂志,2013,12(2):100-102,3.
