临床与实验病理学杂志2013，Vol.29Issue(3)：253-256,4.
乳腺癌中法尼酯X受体的表达及意义
Expression of FXR mRNA in breast cancer and its significance
摘要
Abstract
Purpose To investigate the expression of FXR mRNA and their relationships with ERa, ERfJand clinicopathologic characters in breast carcinoma. Methods Real time quantitative transcription polymerase chain reaction ( RQ RT-PCR) technique was used to detect FXR mRNA expression in 60 cases of invasive breast carcinoma and 25 cases of breast benign lesions. Result The RQ RT-PCR data showed that FXR expression was reduced in invasive breast carcinoma tissues (9. 7 ± 2. 7 ) compared with breast benign lesions tissues (40. 8 ± 7. 9) (P = 0. 007, respectively). Furthermore, FXR mRNA expression was significantly higher in breast carcinomas with lymph node positive (17. 1 ±9.0) than thoses with lymph node negative cases (4. 3 ±2. 9) (P =0. 041). The expression of FXR mRNA was positively correlated with the expression of ER(3 (P =0. 000, r =0. 771) in invasive breast carcinoma tissues but was not associated with the expression of ERa ( P = 0. 051) . Conclusion The data from the current study show that FXR may play various roles in the carcinogenesis of breast cancer. FXR mRNA express at high levels may contribute to lymph node metastasis in breast cancer. The results of this study also indicate that the expression of FXR is positively correlated with the expression of ERpin invasive breast carcinoma.关键词
乳腺肿瘤/法尼酯X受体/转移/逆转录聚合酶链反应法Key words
breast neoplasms/farnesoid X receptor/metastasis/reverse transcription polymerase chain reaction分类
医药卫生引用本文复制引用
慈思慧,张瑰红,曹渊,吴正升,杨枫,徐晓春..乳腺癌中法尼酯X受体的表达及意义[J].临床与实验病理学杂志,2013,29(3):253-256,4.基金项目
安徽省高校省级自然科学研究重点项目(KJ2011A168) （KJ2011A168）
