临床与实验病理学杂志2013，Vol.29Issue(3)：287-291,5.
中枢神经细胞瘤及非典型中枢神经细胞瘤12例临床病理观察
Clinicopathologic analysis of central neurocytoma and atypical central neurocytoma
崔华娟 1王卓才 1陈敬文 1彭大云 1赖日权1
作者信息
摘要
Abstract
Purpose To study the clinicopathologic features of central neurocytoma and atypical central neurocytoma, and to improve the knowledge of central neurocytoma and atypical central neurocytoma. Methods The clinical manifestations, image, histopathologi-cal features, immunohistochemical and electron microscope were analyzed in twelve cases central neurocytoma, and all cases were followed up. Results The most common presenting symptoms were those related to increased intracranial pressure (ICP) , including headache and swirl, few cases accompany with nerve disfunction. Histologically, all tumors composed of uniform medium-sized clear round cells with small neuropil-like structure. The blood vessel of stroma were slight and ramified, calcification could be seen in few cases. Atypia and necrosis could been seen in eight cases and mitoses were less than 2 per 10 high power field. Four cases have tumor cell atypia and mitoses were more than 5 per 10 high power field, necrosis could been seen in two of four cases. Immunohistochemical-ly, the tumor cells of twelve cases were positive for synaptophysin and NeuN had different degree positive. Focally positive for GFAP was seen in five cases. MIB-1 index entirely was less than 2% in eight cases and more than 8% in four cases. Electron microscopic investigation showed there were neuroendocrine granules in the cell cytoplasm and synapses between tumor cells. After two months to seven years follow-up, two cases recurred and one case died due to postoperative subsequent symptom, the other cases were all alive without tumors. Conclusion Central neurocytoma have a favorable prognosis in general, which is difficult to be distinguished histopathogi-cally from oligodendroglioma and ependymoma. Atypical central neurocytoma could easily been mistaken for WHO II grade tumor especially. Immunohistochemical and electron microscope were very important for diagnosis. 关键词
中枢神经细胞瘤/非典型/预后/临床病理Key words
central neurocytom/ atypical/ prognosis/ clinicopathology分类
医药卫生引用本文复制引用
崔华娟,王卓才,陈敬文,彭大云,赖日权..中枢神经细胞瘤及非典型中枢神经细胞瘤12例临床病理观察[J].临床与实验病理学杂志,2013,29(3):287-291,5.
